A maximum of 400 mg/day, given as 200 mg twice daily, may be considered for patients in whom no clinical improvement is noted after several weeks of treatment at 300 mg/day. There should be an interval of at least 8 hours between successive doses. After 3 days of dosing, the dose may be increased to the 300-mg/day target dose, given as 150 mg twice daily. Initiate dosing with 150 mg/day given as a single daily dose in the morning. The usual adult target dose for WELLBUTRIN SR is 300 mg/day, given as 150 mg twice daily. WELLBUTRIN SR may be taken with or without food. WELLBUTRIN SR tablets should be swallowed whole and not crushed, divided, or chewed. There are 490 drug interactions with Wellbutrin (bupropion).To minimize the risk of seizure, increase the dose gradually. Switch to professional interaction data Wellbutrin drug interactions Do not stop using any medications without first talking to your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. In general, you should avoid or limit the use of alcohol while being treated with buPROPion.
If you are prone to frequent or excessive alcohol use, talk to your doctor before starting buPROPion. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk of seizures during treatment with buPROPion. Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks.
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